Dementia/Alzheimer's.

Brain changes precede memory loss:

In some cases the disease is very difficult to detect until it has progressed from mild memory loss to clear impairment, individuals eventually loss all ability to care for themselves.

The Brain structure changes can be seen in clinically normal individuals an average of two years before they are diagnosed with mild cognitive impairment.

In Dementia/Alzheimer's disease cases, lesions known as ( plaques and tangles ) form in the brain, due to the abnormal clumping of two proteins called beta-amyloid and tau.

MRI showed loss of gray matter two to three years before symptoms.

In normal older individuals, MRI of the brain reveals loss of gray matter about two to three years before symptoms of the mind cognitive impairment set in.

Dr. William Thomas